Usefulness of helium-oxygen mixtures in the treatment of mechanically ventilated patients.

Details

Serval ID
serval:BIB_E97E2CD5609A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Usefulness of helium-oxygen mixtures in the treatment of mechanically ventilated patients.
Journal
Current Opinion in Critical Care
Author(s)
Jolliet P., Tassaux D.
ISSN
1070-5295 (Print)
ISSN-L
1070-5295
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
9
Number
1
Pages
45-50
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
The density of helium is markedly lower than that of air or any of its components, leading to a substantial decrease in airway resistance to flow when it is inhaled. In mechanically ventilated patients with obstructive airway disease, replacing the usual air-oxygen mixture with helium-oxygen has been shown to reduce dynamic hyperinflation and intrinsic positive end-expiratory pressure; to decrease lung inflation pressures, respiratory acidosis, and work of breathing; and to improve arterial blood gases. Aerosol delivery to distal airways is enhanced with helium-oxygen. Preliminary data also suggest that the use of helium-oxygen could be a valuable approach to decrease postextubation respiratory distress. However, interference with ventilator function and added costs are two major disadvantages of helium-oxygen. Hence, before its widespread use in mechanically ventilated patients can be recommended, studies are needed to determine whether these favorable short-term effects can influence patient outcome.
Keywords
Anoxia/physiopathology, Helium/therapeutic use, Humans, Oxygen/therapeutic use, Pulmonary Disease, Chronic Obstructive/physiopathology, Pulmonary Disease, Chronic Obstructive/therapy, Respiration, Artificial, Respiratory Mechanics, Respiratory Tract Diseases/physiopathology, Respiratory Tract Diseases/therapy, Tidal Volume
Pubmed
Create date
25/07/2013 14:16
Last modification date
20/08/2019 16:12
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