JNK pathway as therapeutic target to prevent degeneration in the central nervous system

Details

Serval ID
serval:BIB_E8E0BAB1372E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
JNK pathway as therapeutic target to prevent degeneration in the central nervous system
Journal
Advances in Experimental Medicine and Biology
Author(s)
Repici  M., Borsello  T.
ISSN
0065-2598 (Print)
Publication state
Published
Issued date
2006
Volume
588
Pages
145-55
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Abstract
JNKs (c-Jun N- terminal kinases) are important transducing enzymes involved in many faces of cellular regulation such as gene expression, cell proliferation and programmed cell death. The activation of JNK pathway is critical for naturally occurring neuronal death during development as well as for pathological death of adult brain following different insults. In particular, JNKs play an important role in excitotoxicity and all related phenomena. Initial research concentrated on defining the components and organization of JNK signalling cascades, but more recent studies have begun to see JNK as the appropriate target for prevent cell loss. We used a specific JNK inhibitor, the cell permeable peptide D-JNKI1, to block JNK action in neuronal death following excitotoxicity in vitro and cerebral ischemia in vivo. Here we review our recent findings and we discuss the possibility of using D-JNKI1 as a therapeutic agent to prevent cell loss in the central nervous system.
Keywords
Animals Central Nervous System/*physiology Disease Models, Animal Enzyme Inhibitors/pharmacology Hippocampus/metabolism/pathology Humans Ischemia/pathology MAP Kinase Kinase 4/metabolism/*physiology Mice Nerve Degeneration/*pathology/*therapy Neurodegenerative Diseases/*pathology/*therapy Neurons/metabolism Peptides/chemistry/pharmacology Rats
Pubmed
Web of science
Create date
24/01/2008 14:20
Last modification date
20/08/2019 16:11
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