JNK pathway as therapeutic target to prevent degeneration in the central nervous system
Détails
ID Serval
serval:BIB_E8E0BAB1372E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
JNK pathway as therapeutic target to prevent degeneration in the central nervous system
Périodique
Advances in Experimental Medicine and Biology
ISSN
0065-2598 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
588
Pages
145-55
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Research Support, Non-U.S. Gov't
Review
Résumé
JNKs (c-Jun N- terminal kinases) are important transducing enzymes involved in many faces of cellular regulation such as gene expression, cell proliferation and programmed cell death. The activation of JNK pathway is critical for naturally occurring neuronal death during development as well as for pathological death of adult brain following different insults. In particular, JNKs play an important role in excitotoxicity and all related phenomena. Initial research concentrated on defining the components and organization of JNK signalling cascades, but more recent studies have begun to see JNK as the appropriate target for prevent cell loss. We used a specific JNK inhibitor, the cell permeable peptide D-JNKI1, to block JNK action in neuronal death following excitotoxicity in vitro and cerebral ischemia in vivo. Here we review our recent findings and we discuss the possibility of using D-JNKI1 as a therapeutic agent to prevent cell loss in the central nervous system.
Mots-clé
Animals
Central Nervous System/*physiology
Disease Models, Animal
Enzyme Inhibitors/pharmacology
Hippocampus/metabolism/pathology
Humans
Ischemia/pathology
MAP Kinase Kinase 4/metabolism/*physiology
Mice
Nerve Degeneration/*pathology/*therapy
Neurodegenerative Diseases/*pathology/*therapy
Neurons/metabolism
Peptides/chemistry/pharmacology
Rats
Pubmed
Web of science
Création de la notice
24/01/2008 15:20
Dernière modification de la notice
20/08/2019 17:11