Diagnostic Approach to Neuroendocrine Neoplasms of the Gastrointestinal Tract and Pancreas.

Details

Serval ID
serval:BIB_E8B86E8B7FCD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic Approach to Neuroendocrine Neoplasms of the Gastrointestinal Tract and Pancreas.
Journal
Türk Patoloji Dergisi
Author(s)
Uccella S., Sessa F., La Rosa S.
ISSN
1018-5615 (Print)
ISSN-L
1018-5615
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
31
Number
Suppl 1
Pages
113-127
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
The gastroenteropancreatic (GEP) system is the site of origin of about two thirds of all neuroendocrine neoplasms (NENs) of the human body. GEP-NENs encompass a wide spectrum of entities, from very indolent tumors to highly aggressive carcinomas. They represent a challenge for the oncologist and a correct diagnostic approach is crucial for the management of patients. The nomenclature and classification of these tumors have been a matter of debate for more than a century, since their first description by Siegfried Oberdorfer. The last WHO classification provided a robust and easy-to-use tool to prognostically stratify GEP-NENs, based on morphological aspects and on proliferation rate. This review examines current approaches to the diagnosis and prognostic classification of GEP-NENs, focusing on the critical use of morphological parameters and immunohistochemical stainings, including diagnostic, site-specific and prognostic markers. The key issues of the current classification are addressed, including the emerging topics about cases with discordant morphology and proliferative index. Finally, we attempted to highlight the diagnostic pitfalls and the caveats in the use of immunohistochemical stains.
Keywords
Biomarkers, Tumor/analysis, Biopsy, Carcinoma, Neuroendocrine/chemistry, Carcinoma, Neuroendocrine/classification, Diagnostic Errors/prevention & control, Gastrointestinal Neoplasms/chemistry, Gastrointestinal Neoplasms/classification, Humans, Immunohistochemistry, Multimodal Imaging/methods, Pancreatic Neoplasms/chemistry, Pancreatic Neoplasms/classification, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Tomography, X-Ray Computed
Pubmed
Open Access
Yes
Create date
06/09/2016 12:48
Last modification date
20/08/2019 17:11
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