How Donor Profile Affects the Outcome of Heart Transplant: A New Score to Predict Primary Graft Failure

Details

Serval ID
serval:BIB_E89410DC02D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
How Donor Profile Affects the Outcome of Heart Transplant: A New Score to Predict Primary Graft Failure
Journal
Journal of Thoracic Disease and Cardiothoracic Surgery
Author(s)
Hoti E., Hullin R., Kirsch M., Schütz F., Tozzi P.
ISSN
2693-2156
Publication state
Published
Issued date
21/11/2023
Peer-reviewed
Oui
Volume
4
Number
5
Pages
01-11
Language
english
Abstract
Aim: This study aimed to identify demographic and clinical parameters in donors that could predict the ischaemic time
tolerated by the heart transplant in order to increase the number of heart transplantation performed in our centre by
expanding the area of graft recruitment.
Methods: A single site retrospective study was conducted on 116 heart transplantations performed in our centre between
2013 and 2021. Multivariate logistic regression analyses were used to identify interactions between the different donor
parameters.
Results: Sex, weight, height, total graft ischemic time were the donor parameters independently correlated with primary
graft failure (p < 0.1). The logistic regression model included 11 variables, with an AUC of 0.81, this model appears to
perform well in the prediction of primary graft failure in the recipient.
Conclusions: A predictive score of primary graft failure was created based on identified donors parameters that may help
identify grafts with a higher tolerance to ischemia.
Keywords
Heart transplantation, organ donor, primary graft failure, data base analysis
Open Access
Yes
Create date
28/05/2024 17:18
Last modification date
03/06/2024 7:36
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