GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis.

Details

Serval ID
serval:BIB_E8138BB17B01
Type
Article: article from journal or magazin.
Collection
Publications
Title
GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis.
Journal
Methods in molecular biology
Author(s)
Labouèbe G., Thorens B., Lamy C.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
1713
Pages
255-267
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Brain glucose sensing plays an essential role in the regulation of energy homeostasis. Recent publications report that neurons expressing glucose transporter GLUT2 act as glucose sensors in different regions of the brain and contribute to the control of glucose homeostasis and feeding behavior. In this chapter we describe the methods used to explore glucose sensing in genetically tagged GLUT2-expressing neurons with slice electrophysiology.
Keywords
Animals, Brain/physiology, Electrophysiological Phenomena, Gene Expression, Glucose/metabolism, Glucose Transporter Type 2/genetics, Glucose Transporter Type 2/metabolism, Male, Mice, Molecular Imaging, Neurons/physiology, Patch-Clamp Techniques, Electrophysiology, GLUT2, Glucose sensing, Juxtacellular, NTS, Neurons, PVT, Whole-cell
Pubmed
Create date
14/12/2017 18:05
Last modification date
20/08/2019 16:10
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