Mechanisms of synaptic depression triggered by metabotropic glutamate receptors.

Details

Serval ID
serval:BIB_E7A9EBE9C380
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mechanisms of synaptic depression triggered by metabotropic glutamate receptors.
Journal
Cellular and molecular life sciences : CMLS
Author(s)
Bellone C., Lüscher C., Mameli M.
ISSN
1420-682X (Print)
ISSN-L
1420-682X
Publication state
Published
Issued date
09/2008
Peer-reviewed
Oui
Volume
65
Number
18
Pages
2913-2923
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

Keywords
Animals, Excitatory Postsynaptic Potentials/physiology, Humans, Long-Term Synaptic Depression/physiology, Neuronal Plasticity/physiology, Protein Isoforms/metabolism, Receptors, Metabotropic Glutamate/metabolism, Synapses/physiology, Synaptic Transmission/physiology
Pubmed
Web of science
Create date
24/03/2017 14:22
Last modification date
20/08/2019 16:10
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