Mechanisms of synaptic depression triggered by metabotropic glutamate receptors.
Détails
ID Serval
serval:BIB_E7A9EBE9C380
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mechanisms of synaptic depression triggered by metabotropic glutamate receptors.
Périodique
Cellular and molecular life sciences : CMLS
ISSN
1420-682X (Print)
ISSN-L
1420-682X
Statut éditorial
Publié
Date de publication
09/2008
Peer-reviewed
Oui
Volume
65
Numéro
18
Pages
2913-2923
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
Mots-clé
Animals, Excitatory Postsynaptic Potentials/physiology, Humans, Long-Term Synaptic Depression/physiology, Neuronal Plasticity/physiology, Protein Isoforms/metabolism, Receptors, Metabotropic Glutamate/metabolism, Synapses/physiology, Synaptic Transmission/physiology
Pubmed
Web of science
Création de la notice
24/03/2017 15:22
Dernière modification de la notice
20/08/2019 17:10
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