In vivo pig models of venous thrombosis mimicking human disease.

Details

Serval ID
serval:BIB_E7A733219CD7
Type
Article: article from journal or magazin.
Collection
Publications
Title
In vivo pig models of venous thrombosis mimicking human disease.
Journal
Thrombosis and Haemostasis
Author(s)
Kang C., Bonneau M., Brouland J.P., Bal dit Sollier C., Drouet L.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
89
Number
2
Pages
256-263
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Most animal models of venous thrombosis involve acute thrombosis with hypercoagulability in small rodents. To better replicate human disease, we developed two models in the pig, a species similar to humans in size and in vascular and coagulation reactivity. One model involves de-endothelialisation with 50% or 80% stenosis and the other replacement of a venous segment by a Gore-Tex vascular prosthesis. Both models were tested with and without acute induced hypercoagulability (thromboplastin infusion). Thrombi obtained without thromboplastin infusion were composed of a multilayered platelet and a fibrin meshwork structure similar to that usually found in humans. With thromboplastin infusion, the thrombi were homogeneous fibrin structures imprisoning red blood cells. The high incidence of thrombosis obtained with the 80% stenosis model would be useful for studying anticoagulant treatments, whereas the low incidence with 50% stenosis would be useful for evaluating procoagulant effects of conditions or treatments. These new models shed further light on the development of venous thrombi under conditions similar to those seen in humans and may prove useful for investigating anticoagulant and procoagulant effects.
Keywords
Animals, Blood Vessel Prosthesis, Chronic Disease, Constriction, Pathologic, Disease Progression, Endothelium, Vascular/injuries, Fibrin/analysis, Hemorheology, Jugular Veins/pathology, Jugular Veins/surgery, Models, Animal, Swine/blood, Swine/surgery, Thrombophilia/chemically induced, Thromboplastin/toxicity, Venous Thrombosis/blood, Venous Thrombosis/etiology
Pubmed
Web of science
Create date
13/10/2015 9:34
Last modification date
20/08/2019 16:10
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