In vivo pig models of venous thrombosis mimicking human disease.
Détails
ID Serval
serval:BIB_E7A733219CD7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo pig models of venous thrombosis mimicking human disease.
Périodique
Thrombosis and Haemostasis
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
89
Numéro
2
Pages
256-263
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Most animal models of venous thrombosis involve acute thrombosis with hypercoagulability in small rodents. To better replicate human disease, we developed two models in the pig, a species similar to humans in size and in vascular and coagulation reactivity. One model involves de-endothelialisation with 50% or 80% stenosis and the other replacement of a venous segment by a Gore-Tex vascular prosthesis. Both models were tested with and without acute induced hypercoagulability (thromboplastin infusion). Thrombi obtained without thromboplastin infusion were composed of a multilayered platelet and a fibrin meshwork structure similar to that usually found in humans. With thromboplastin infusion, the thrombi were homogeneous fibrin structures imprisoning red blood cells. The high incidence of thrombosis obtained with the 80% stenosis model would be useful for studying anticoagulant treatments, whereas the low incidence with 50% stenosis would be useful for evaluating procoagulant effects of conditions or treatments. These new models shed further light on the development of venous thrombi under conditions similar to those seen in humans and may prove useful for investigating anticoagulant and procoagulant effects.
Mots-clé
Animals, Blood Vessel Prosthesis, Chronic Disease, Constriction, Pathologic, Disease Progression, Endothelium, Vascular/injuries, Fibrin/analysis, Hemorheology, Jugular Veins/pathology, Jugular Veins/surgery, Models, Animal, Swine/blood, Swine/surgery, Thrombophilia/chemically induced, Thromboplastin/toxicity, Venous Thrombosis/blood, Venous Thrombosis/etiology
Pubmed
Web of science
Création de la notice
13/10/2015 10:34
Dernière modification de la notice
20/08/2019 17:10