Relaxivity of liposomal paramagnetic MRI contrast agents.

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Serval ID
serval:BIB_E74E3A6EA9B7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Relaxivity of liposomal paramagnetic MRI contrast agents.
Journal
Magma (new York, N.y.)
Author(s)
Strijkers G.J., Mulder W.J., van Heeswijk R.B., Frederik P.M., Bomans P., Magusin P.C., Nicolay K.
ISSN
0968-5243 (Print)
ISSN-L
0968-5243
Publication state
Published
Issued date
2005
Volume
18
Number
4
Pages
186-192
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Paramagnetic liposomes, spherical particles formed by a lipid bilayer, are able to accommodate a high payload of Gd-containing lipid and therefore can serve as a highly potent magnetic resonance imaging contrast agent. In this paper the relaxation properties of paramagnetic liposomes were studied as a function of composition, temperature and magnetic field strength. The pegylated liposomes with a diameter of approximately 100 nm were designed for favorable pharmacokinetic properties in vivo. The proton relaxivity, i.e. the T1 relaxation rate per mmol of Gd(III) ions, of liposomes with unsaturated DOPC phospholipids was higher than those with saturated DSPC lipids. Addition of cholesterol was essential to obtain monodisperse liposomes and led to a further, although smaller, increase of the relaxivity. Nuclear magnetic relaxation dispersion measurements showed that the relaxivity was limited by water exchange. These results show that these paramagnetic liposomes are very effective contrast agents, making them excellent candidates for many applications in magnetic resonance imaging.
Keywords
Biocompatible Materials/analysis, Biocompatible Materials/chemistry, Contrast Media/analysis, Contrast Media/chemistry, Drug Delivery Systems/methods, Drug Stability, Gadolinium DTPA/analysis, Gadolinium DTPA/chemistry, Lipid Bilayers/analysis, Lipid Bilayers/chemistry, Liposomes/analysis, Liposomes/chemistry, Magnetic Resonance Imaging/methods, Materials Testing, Nanostructures/analysis, Nanostructures/chemistry, Phase Transition, Phospholipids/analysis, Phospholipids/chemistry
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13/12/2012 16:32
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20/08/2019 16:10
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