Relaxivity of liposomal paramagnetic MRI contrast agents.

Détails

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ID Serval
serval:BIB_E74E3A6EA9B7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Relaxivity of liposomal paramagnetic MRI contrast agents.
Périodique
Magma (new York, N.y.)
Auteur(s)
Strijkers G.J., Mulder W.J., van Heeswijk R.B., Frederik P.M., Bomans P., Magusin P.C., Nicolay K.
ISSN
0968-5243 (Print)
ISSN-L
0968-5243
Statut éditorial
Publié
Date de publication
2005
Volume
18
Numéro
4
Pages
186-192
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Paramagnetic liposomes, spherical particles formed by a lipid bilayer, are able to accommodate a high payload of Gd-containing lipid and therefore can serve as a highly potent magnetic resonance imaging contrast agent. In this paper the relaxation properties of paramagnetic liposomes were studied as a function of composition, temperature and magnetic field strength. The pegylated liposomes with a diameter of approximately 100 nm were designed for favorable pharmacokinetic properties in vivo. The proton relaxivity, i.e. the T1 relaxation rate per mmol of Gd(III) ions, of liposomes with unsaturated DOPC phospholipids was higher than those with saturated DSPC lipids. Addition of cholesterol was essential to obtain monodisperse liposomes and led to a further, although smaller, increase of the relaxivity. Nuclear magnetic relaxation dispersion measurements showed that the relaxivity was limited by water exchange. These results show that these paramagnetic liposomes are very effective contrast agents, making them excellent candidates for many applications in magnetic resonance imaging.
Mots-clé
Biocompatible Materials/analysis, Biocompatible Materials/chemistry, Contrast Media/analysis, Contrast Media/chemistry, Drug Delivery Systems/methods, Drug Stability, Gadolinium DTPA/analysis, Gadolinium DTPA/chemistry, Lipid Bilayers/analysis, Lipid Bilayers/chemistry, Liposomes/analysis, Liposomes/chemistry, Magnetic Resonance Imaging/methods, Materials Testing, Nanostructures/analysis, Nanostructures/chemistry, Phase Transition, Phospholipids/analysis, Phospholipids/chemistry
Pubmed
Création de la notice
13/12/2012 16:32
Dernière modification de la notice
20/08/2019 16:10
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