100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.

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State: Public
Version: Final published version
Serval ID
serval:BIB_E6E1F47DF997
Type
Article: article from journal or magazin.
Collection
Publications
Title
100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.
Journal
BMC Genomics
Author(s)
Goebel J., Promerová M., Bonadonna F., McCoy K.D., Serbielle C., Strandh M., Yannic G., Burri R., Fumagalli L.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
18
Number
1
Pages
460
Language
english
Abstract
Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.
Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.
Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

Keywords
Biotechnology, Genetics, Birds, Birth-death evolution, Concerted evolution, Gene conversion, Gene duplication, Major histocompatibility complex, Recombination
Pubmed
Web of science
Open Access
Yes
Create date
01/06/2017 17:35
Last modification date
20/08/2019 17:09
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