The type III secretion system tip complex and translocon.

Details

Serval ID
serval:BIB_E55332556FF5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The type III secretion system tip complex and translocon.
Journal
Molecular Microbiology
Author(s)
Mueller C.A., Broz P., Cornelis G.R.
ISSN
1365-2958 (Electronic)
ISSN-L
0950-382X
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
68
Number
5
Pages
1085-1095
Language
english
Abstract
The type III secretion machinery of Gram-negative bacteria, also known as the injectisome or needle complex, is composed of a basal body spanning both bacterial membranes and the periplasm, and an external needle protruding from the bacterial surface. A set of three proteins, two hydrophobic and one hydrophilic, are required to allow translocation of proteins from the bacterium to the host cell cytoplasm. These proteins are involved in the formation of a translocation pore, the translocon, in the host cell membrane. Exciting progress has recently been made on the interaction between the translocators and the injectisome needle and the assembly of the translocon in the host cell membrane. As expected, the two hydrophobic translocators insert into the target cell membrane. Unexpectedly, the third, hydrophilic translocator, forms a complex on the distal end of the injectisome needle, the tip complex, and serves as an assembly platform for the two hydrophobic translocators.

Keywords
Antigens, Bacterial/genetics, Antigens, Bacterial/physiology, Bacterial Proteins/genetics, Bacterial Proteins/isolation & purification, Bacterial Proteins/metabolism, Bacterial Proteins/secretion, Biological Transport, Cytoplasm/metabolism, Gram-Negative Bacteria/genetics, Gram-Negative Bacteria/pathogenicity, Membrane Proteins/metabolism, Pore Forming Cytotoxic Proteins
Pubmed
Web of science
Create date
25/10/2017 10:05
Last modification date
20/08/2019 16:08
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