Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.

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Serval ID
serval:BIB_E4D0E1AAA380
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.
Journal
Virchows Archiv
Author(s)
Saglietti C., Schneider V., Bongiovanni M., Missiaglia E., Bisig B., Dorta G., Demartines N., Sempoux C., La Rosa S.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
12/2019
Peer-reviewed
Oui
Volume
475
Number
6
Pages
789-794
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have recently been described and include oncocytic, spindle, clear, and pleomorphic cell types. This wide histological spectrum represents a challenge in the diagnostic task for pathologists. Molecular mechanisms involved in the onset and progression of ACCs are not completely known, but, in general, they differ from those observed in ductal adenocarcinomas or neuroendocrine neoplasms of the pancreas and frequently include alterations in the APC/β-catenin pathway. In the present paper, we describe a new variant of ACC showing thyroid-like follicular features and CTNNB1 mutation. This phenotype needs to be included in the spectrum of morphological presentation of ACC.
Keywords
Carcinoma, Acinar Cell/diagnosis, Carcinoma, Acinar Cell/genetics, Carcinoma, Acinar Cell/pathology, Diagnosis, Differential, Humans, Male, Middle Aged, Mutation/genetics, Pancreatic Neoplasms/diagnosis, Pancreatic Neoplasms/pathology, Thyroid Gland/pathology, beta Catenin/genetics, beta Catenin/metabolism, Acinar cell carcinoma, Differential diagnosis, Morphology, Pancreas, Thyroid-like
Pubmed
Web of science
Create date
26/07/2019 14:36
Last modification date
04/01/2020 7:17
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