What to compare and how: Comparative transcriptomics for Evo-Devo.

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Serval ID
serval:BIB_E322E5E2A13A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
What to compare and how: Comparative transcriptomics for Evo-Devo.
Journal
Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Author(s)
Roux J., Rosikiewicz M., Robinson-Rechavi M.
ISSN
1552-5015 (Electronic)
ISSN-L
1552-5007
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
324
Number
4
Pages
372-382
Language
english
Abstract
Evolutionary developmental biology has grown historically from the capacity to relate patterns of evolution in anatomy to patterns of evolution of expression of specific genes, whether between very distantly related species, or very closely related species or populations. Scaling up such studies by taking advantage of modern transcriptomics brings promising improvements, allowing us to estimate the overall impact and molecular mechanisms of convergence, constraint or innovation in anatomy and development. But it also presents major challenges, including the computational definitions of anatomical homology and of organ function, the criteria for the comparison of developmental stages, the annotation of transcriptomics data to proper anatomical and developmental terms, and the statistical methods to compare transcriptomic data between species to highlight significant conservation or changes. In this article, we review these challenges, and the ongoing efforts to address them, which are emerging from bioinformatics work on ontologies, evolutionary statistics, and data curation, with a focus on their implementation in the context of the development of our database Bgee (http://bgee.org). J. Exp. Zool. (Mol. Dev. Evol.) 324B: 372-382, 2015. © 2015 Wiley Periodicals, Inc.
Pubmed
Web of science
Create date
20/02/2015 10:11
Last modification date
20/08/2019 17:06
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