Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions.

Details

Serval ID
serval:BIB_E27E742A8A3D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions.
Journal
Journal of Controlled Release
Author(s)
Peyre M., Audran R., Estevez F., Corradin G., Gander B., Sesardic D., Johansen P.
ISSN
0168-3659
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
99
Number
3
Pages
345-355
Language
english
Abstract
Biodegradable microspheres may represent a potential tool for the delivery of combination vaccines. We demonstrate strong immunogenicity of five co-encapsulated antigens after a single subcutaneous inoculation in guinea pigs. Tetanus- and diphtheria-specific antibodies were not significantly affected by the presence of either antigen or by the presence of pertussis or Haemophilus influenzae type b (Hib) antigens. Microsphere formulations gave better protection against diphtheria toxin than did two injections of a licensed tetravalent vaccine. Finally, a synthetic malaria peptide antigen (PfCS) also encapsulated in PLGA microspheres increased diphtheria and tetanus-specific immunity and improved protection against diphtheria. These findings demonstrate the potential of microspheres as an alternative and promising strategy for combination vaccines with a further aptitude in reducing the number of inoculations required to gain functional immunity.
Keywords
Animals, Antibodies, Bacterial, Antibody Specificity, Antigens, Bacterial, Biodegradation, Environmental, Diphtheria Toxin, Drug Evaluation, Preclinical, Female, Guinea Pigs, Haemophilus influenzae type b, Humans, Immunization, Infant, Injections, Subcutaneous, Lactic Acid, Malaria Vaccines, Mice, Microspheres, Neutralization Tests, Peptides, Plasmodium falciparum, Polyglycolic Acid, Polymers, Vaccines, Combined, Vaccines, Synthetic
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 17:06
Usage data