Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.
Details
Serval ID
serval:BIB_E23955380239
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.
Journal
Biology of the Cell
ISSN
0248-4900 (Print)
ISSN-L
0248-4900
Publication state
Published
Issued date
2004
Volume
96
Number
5
Pages
327-333
Language
english
Abstract
The aim of a large number of studies on G protein-coupled receptors was centered on understanding the structural basis of their main functional properties. Here, we will briefly review the results obtained on the alpha1-adrenergic receptor subtypes belonging to the rhodopsin-like family of receptors. These findings contribute, on the one hand, to further understand the molecular basis of adrenergic transmission and, on the other, to provide some generalities on the structure-functional relationship of G protein-coupled receptors.
Keywords
Amino Acid Sequence, Animals, DNA Mutational Analysis, Humans, Models, Biological, Models, Molecular, Molecular Sequence Data, Mutation, Protein Binding, Receptors, Adrenergic, alpha-1/metabolism, Receptors, G-Protein-Coupled/chemistry, Receptors, G-Protein-Coupled/physiology, Rhodopsin/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 12:06
Last modification date
20/08/2019 17:06
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