The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major.

Details

Serval ID
serval:BIB_E0CF6FB49866
Type
Article: article from journal or magazin.
Collection
Publications
Title
The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major.
Journal
European Journal of Immunology
Author(s)
Revaz-Breton M., Ronet C., Ives A., Torre Y.H., Masina S., Tacchini-Cottier F., Launois P.
ISSN
1521-4141[electronic], 0014-2980[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
40
Number
6
Pages
1697-1707
Language
english
Abstract
Host resistance to Leishmania major is highly dependent on the development of a Th1 immune response. The TLR adaptator myeloid differentiation protein 88 (MyD88) has been implicated in the Th1 immune response associated with the resistant phenotype observed in C57BL/6 mice after infection with L. major. To investigate whether the MyD88 pathway is differentially used by distinct substrains of parasites, MyD88(-/-) C57BL/6 mice were infected with two substrains of L. major, namely L. major LV39 and L. major IR75. MyD88(-/-) mice were susceptible to both substrains of L. major, although with different kinetics of infection. The mechanisms involved during the immune response associated with susceptibility of MyD88(-/-) mice to L. major is however, parasite substrain-dependent. Susceptibility of MyD88(-/-) mice infected with L. major IR75 is a consequence of Th2 immune-deviation, whereas susceptibility of MyD88(-/-) mice to infection with L. major LV39 resulted from an impaired Th1 response. Depletion of regulatory T cells (Treg) partially restored IFN-gamma secretion and the Th1 immune response in MyD88(-/-) mice infected with L. major LV39, demonstrating a role of Treg activity in the development of an impaired Th1 response in these mice.
Keywords
Animals, Cytokines/biosynthesis, Disease Susceptibility/immunology, Enzyme-Linked Immunosorbent Assay, Female, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Myeloid Differentiation Factor 88/immunology, Signal Transduction/immunology, T-Lymphocyte Subsets/immunology
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2010 11:50
Last modification date
20/08/2019 17:05
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