Chloride transport in the proximal renal tubule

Details

Serval ID
serval:BIB_E0ADD8AF7D43
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Chloride transport in the proximal renal tubule
Journal
Annual Review of Physiology
Author(s)
Schild  L., Giebisch  G., Green  R.
ISSN
0066-4278 (Print)
Publication state
Published
Issued date
1988
Volume
50
Pages
97-110
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Abstract
Our knowledge of chloride transport along the nephron has greatly expanded. Whereas for a long time it was assumed that chloride ions were reabsorbed entirely passively with sodium--the "mendicant" role of chloride, more recent studies suggest that several distinct reabsorptive transport mechanisms operate in parallel. Accordingly, a new model of proximal chloride transport has evolved that includes both active, transcellular as well as passive, intercellular transport pathways. Transcellular chloride reabsorption involves anion exchange mechanisms in both the luminal and peritubular cell membranes, processes that also depend on sodium, hydrogen, and bicarbonate ions. Chloride transport is thus intimately related to sodium and fluid transport as well as to cell acid-base metabolism. Unresolved problems concern the relative magnitude of transcellular and paracellular chloride transport and the details of luminal and basolateral chloride translocation steps.
Keywords
Animals Chlorides/*pharmacokinetics Humans Kidney Tubules, Proximal/*physiology
Pubmed
Web of science
Create date
24/01/2008 12:56
Last modification date
20/08/2019 16:04
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