Recording and reporting of ultra-high dose rate "FLASH" delivery for preclinical and clinical settings.
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UNIL restricted access
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_E03324B6E50A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Recording and reporting of ultra-high dose rate "FLASH" delivery for preclinical and clinical settings.
Journal
Radiotherapy and oncology
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
11/2024
Peer-reviewed
Oui
Volume
200
Pages
110507
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and dosimetry of preclinical and translational studies may have contributed to a reproducibility crisis of radiobiological data in the field. Consequently, the development of a common terminology, as well as common recording, reporting, dosimetry, and metrology standards is required. In the context of UHDR irradiations, the temporal dose delivery parameters are of importance, and under-reporting of these parameters is also a concern.This work proposes a standardization of terminology, recording, and reporting to enhance comparability of both preclinical and clinical UHDR studies and and to allow retrospective analyses to aid the understanding of the conditions which give rise to the FLASH effect.
Keywords
Humans, Radiotherapy Dosage, Animals, Neoplasms/radiotherapy, FLASH radiotherapy, Recording, Reporting, Terminology, Ultra-high dose rate radiotherapy
Pubmed
Web of science
Create date
13/09/2024 15:06
Last modification date
11/10/2024 19:14