Topological origins of chromosomal territories.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_E01F9D39E9FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Topological origins of chromosomal territories.
Journal
Nucleic Acids Research
Author(s)
Dorier J., Stasiak A.
ISSN
1362-4962[electronic], 0305-1048[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
37
Number
19
Pages
6316-6322
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Using freely jointed polymer model we compare equilibrium properties of crowded polymer chains whose segments are either permeable or not permeable for other segments to pass through. In particular, we addressed the question whether non-permeability of long chain molecules, in the absence of excluded volume effect, is sufficient to compartmentalize highly crowded polymer chains, similarly to what happens during formation of chromosomal territories in interphase nuclei. Our results indicate that even polymers without excluded volume compartmentalize and show strongly reduced intermingling when they are mutually non-permeable. Judging from the known fact that chromatin fibres originating from different chromosomes show very limited intermingling in interphase nuclei, we propose that regular chromatin fibres during chromosome decondensation can hardly serve as a substrate of cellular type II DNA topoisomerases.
Keywords
Biopolymers/chemistry, Chromosomes/chemistry, Models, Molecular
Pubmed
Web of science
Open Access
Yes
Create date
18/11/2009 13:25
Last modification date
20/08/2019 17:04
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