Topological origins of chromosomal territories.

Détails

Ressource 1Télécharger: BIB_E01F9D39E9FE.P001.pdf (5576.64 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_E01F9D39E9FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Topological origins of chromosomal territories.
Périodique
Nucleic Acids Research
Auteur(s)
Dorier J., Stasiak A.
ISSN
1362-4962[electronic], 0305-1048[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
37
Numéro
19
Pages
6316-6322
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Using freely jointed polymer model we compare equilibrium properties of crowded polymer chains whose segments are either permeable or not permeable for other segments to pass through. In particular, we addressed the question whether non-permeability of long chain molecules, in the absence of excluded volume effect, is sufficient to compartmentalize highly crowded polymer chains, similarly to what happens during formation of chromosomal territories in interphase nuclei. Our results indicate that even polymers without excluded volume compartmentalize and show strongly reduced intermingling when they are mutually non-permeable. Judging from the known fact that chromatin fibres originating from different chromosomes show very limited intermingling in interphase nuclei, we propose that regular chromatin fibres during chromosome decondensation can hardly serve as a substrate of cellular type II DNA topoisomerases.
Mots-clé
Biopolymers/chemistry, Chromosomes/chemistry, Models, Molecular
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/11/2009 13:25
Dernière modification de la notice
20/08/2019 17:04
Données d'usage