Unaltered glucose-induced thermogenesis in Graves' disease.
Details
Serval ID
serval:BIB_DFFF62D82ED9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Unaltered glucose-induced thermogenesis in Graves' disease.
Journal
American Journal of Clinical Nutrition
ISSN
0002-9165 (Print)
ISSN-L
0002-9165
Publication state
Published
Issued date
1986
Volume
43
Number
5
Pages
738-744
Language
english
Abstract
The thermogenic response to a 100-g oral glucose challenge was studied in 12 patients with Graves' disease using continuous indirect calorimetry. Seven hyperthyroid patients were reinvestigated under the same experimental conditions after medical therapy. The mean net increase in energy expenditure (delta EE) following the glucose challenge was the same in hyperthyroid patients as compared to a control group (delta EE = +0.15 +/- 0.02 and 0.15 +/- 0.01 kcal/min, respectively) and the treated patients (delta EE = +0.11 +/- 0.03 kcal/min ns). When expressed as a percentage of the energy content of the glucose challenge, the mean glucose induced thermogenesis was similar in all three groups: 7.0 +/- 1.0%, 7.4 +/- 0.5%, and 5.5 +/- 1.3% in hyperthyroid, control subjects, and treated patients, respectively. It is concluded that the high energy requirement of hyperthyroid patients is due primarily to an elevated resting energy expenditure. The postprandial thermogenesis in itself does not contribute to the elevated fuel utilization in Graves' disease.
Keywords
Adult, Antithyroid Agents/therapeutic use, Body Temperature Regulation/drug effects, Energy Metabolism/drug effects, Female, Glucose/diagnostic use, Graves Disease/drug therapy, Graves Disease/metabolism, Humans, Male, Middle Aged, Pulmonary Gas Exchange, Rest, Triiodothyronine/blood
Pubmed
Web of science
Create date
21/01/2008 14:08
Last modification date
20/08/2019 17:04