Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: A systematic review and meta-analysis.

Details

Serval ID
serval:BIB_DCCBD6B537B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: A systematic review and meta-analysis.
Journal
American journal of transplantation
Author(s)
Fernández-Ruiz M., Giménez E., Lora D., Aguado J.M., Pascual M., Manuel O.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
04/2019
Peer-reviewed
Oui
Volume
19
Number
4
Pages
1072-1085
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mannose-binding lectin (MBL) is a soluble pattern recognition molecule involved in complement activation. Single nucleotide polymorphisms (SNPs) in the MBL2 gene have been associated with susceptibility to infection, although data in solid organ transplant recipients remains inconclusive. This meta-analysis was primarily aimed at investigating the association between posttransplant bacterial and fungal infection and variant alleles of MBL2 gene SNPs in the promoter/5' untranslated region and exon 1. Cytomegalovirus (CMV) infection and/or disease were considered secondary outcomes. PubMed, EMBASE, and Web of Knowledge were searched for relevant articles up to August 2018. Eleven studies (comprising 1858 patients) were included, with liver transplant (LT) recipients accounting for 80.4% of the pooled population. As compared to high-MBL expression haplotypes (YA/YA, YA/XA), any MBL-deficient haplotype was associated with an increased risk of posttransplant bacterial and fungal infections (risk ratio [RR]: 1.30; P = .04). Low/null-MBL expression haplotypes (XA/O, O/O) also increased the risk of primary outcome (RR: 1.51; P = .008) and CMV events (RR: 1.50; P = .006). No effect was observed for individual promoter SNPs. In conclusion, MBL-deficient haplotypes are associated with a significant, albeit moderate, increase in the risk of posttransplant infection, with this association being mainly restricted to LT recipients.
Keywords
clinical research/practice, complication: infectious, genetics, immune deficiency, infection and infectious agents, infectious disease, meta-analysis
Pubmed
Web of science
Create date
07/11/2018 13:12
Last modification date
20/08/2019 17:01
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