Oculopalatal tremor: current concepts and new observations.
Details
Serval ID
serval:BIB_DCB19C991AAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oculopalatal tremor: current concepts and new observations.
Journal
Current Opinion In Neurology
ISSN
1473-6551 (Electronic)
ISSN-L
1080-8248
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
26
Number
1
Pages
67-73
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: Oculopalatal tremor (OPT) is an acquired disorder resulting from the interruption of a specific brainstem circuitry, the dentato-rubro-olivary pathway or Guillain-Mollaret triangle. The recent literature on OPT and olivary hypertrophy was reviewed with specific interest regarding causes, diagnostic procedures, physiopathology and therapies.
RECENT FINDINGS: OPT is associated with inferior olivary hypertrophy, and recent findings have provided a better understanding of its intimate mechanisms. A dual-mechanism model, combining an oscillator (inferior olive) and a modulator/amplifier (cerebellum), best explains the development of OPT. Electrotonic coupling and specific Ca channels contribute to oscillations of inferior olivary nucleus neurons in OPT. Improvement of visual symptoms can be achieved with oral gabapentin or memantine.
SUMMARY: Both the neuronal circuitry and the physiopathology of OPT are now better understood. This opens up an era of specific therapy for this rare cause of disabling oscillopsia.
RECENT FINDINGS: OPT is associated with inferior olivary hypertrophy, and recent findings have provided a better understanding of its intimate mechanisms. A dual-mechanism model, combining an oscillator (inferior olive) and a modulator/amplifier (cerebellum), best explains the development of OPT. Electrotonic coupling and specific Ca channels contribute to oscillations of inferior olivary nucleus neurons in OPT. Improvement of visual symptoms can be achieved with oral gabapentin or memantine.
SUMMARY: Both the neuronal circuitry and the physiopathology of OPT are now better understood. This opens up an era of specific therapy for this rare cause of disabling oscillopsia.
Pubmed
Web of science
Create date
14/01/2013 11:42
Last modification date
20/08/2019 16:01