Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis.
Details
Serval ID
serval:BIB_DC973C5BE40C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis.
Journal
European journal of pediatrics
ISSN
0340-6199
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
152
Number
9
Pages
776-8
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Review - Publication Status: ppublish
Abstract
We describe a patient with recurrent respiratory papillomatosis (RRP) associated with human papilloma virus (HPV), who developed a fatal squamous cell carcinoma of the lung. At the age of 1 year he presented with hoarseness, dyspnoea and inspiratory stridor but the diagnosis of RRP was made only 1 year later. At the age of 4 years he was tracheostomized because of upper airway obstruction. In spite of multiple surgical excisions and topic treatment with 5-fluorouracil the papillomata extended to the lung parenchyma. At the age of 16 years he developed a squamous-cell carcinoma of the lung and died 4 months later. Transformation to pulmonary carcinoma is a rare complication in non-irradiated patients with lung papillomatosis. We found only 11 similar cases in the literature.
Keywords
Adolescent, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Humans, Lung Neoplasms, Male, Neoplasm Recurrence, Local, Papilloma, Papillomaviridae, Papillomavirus Infections, Respiratory Tract Neoplasms, Tumor Virus Infections
Pubmed
Web of science
Create date
25/01/2008 10:06
Last modification date
20/08/2019 16:01