Environment-driven responses in progressive supranuclear palsy
Details
Serval ID
serval:BIB_DC44A9C12843
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Environment-driven responses in progressive supranuclear palsy
Journal
Journal of the Neurological Sciences
ISSN
0022-510X (Print)
Publication state
Published
Issued date
05/1995
Volume
130
Number
1
Pages
104-11
Notes
Case Reports
Journal Article --- Old month value: May
Journal Article --- Old month value: May
Abstract
The neurological signs and behaviors that accompany degenerative diseases associated with fronto-striatal dysfunction are incompletely described. We observed several novel environmentally-driven behaviors in seven patients with progressive supranuclear palsy (PSP). All patients had cognitive deficits with greatest impairments on tests of frontal lobe function, and frontal lobe cerebral perfusion was significantly reduced in 4 of the 5 who had single photon emission computed tomography (SPECT) brain scans. Visual grasping, in which a patient's gaze was attracted to an incidental object in the environment such as a TV set or mirror, was preeminent. Once fixed, there was inability to release the gaze and shift to another object. In other instances, removing a table placed in front of a patient or unbuckling of his seat belt would make him stand up, which was impossible on command. Similarly, playing music would induce rhythmic foot beating, which was never obtained on command. There were compulsive utilization behaviors, such as repetitively picking up and replacing the telephone for no apparent reason. As expected, there were signs of heightened facial reflexes, grasp reflexes, apraxia of eyelid opening, echolalia and echopraxia. We postulate that these stimuli-oriented behaviors stem from parietal lobe disinhibition due to fronto-striatal dysfunction.
Keywords
Aged
Amphetamines/diagnostic use
Basal Ganglia/blood supply
Behavior/*physiology
Cerebrovascular Circulation/physiology
Compulsive Behavior
Cues
Echolalia/etiology/psychology
*Environment
Female
Frontal Lobe/blood supply
Humans
Male
Orientation/physiology
Reward
Supranuclear Palsy, Progressive/physiopathology/*psychology
Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Create date
25/01/2008 11:45
Last modification date
20/08/2019 16:01