Two-kidney, one clip and one-kidney, one clip hypertension in mice.
Details
Serval ID
serval:BIB_DB833FA5D872
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Two-kidney, one clip and one-kidney, one clip hypertension in mice.
Journal
Hypertension
ISSN
0194-911X
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
29
Number
4
Pages
1025-30
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The mouse remains the animal of choice in transgenic experiments, creating a need for methods of evaluating the physiology of genetically modified animals. We have established and characterized two murine models of renovascular hypertension known as the two-kidney, one clip and one-kidney, one clip models. The appropriate size of the clip lumen needed to induce high blood pressure was determined to be 0.12 mm. Clips with a lumen of 0.11 mm induced a high percentage of renal infarction, and clips with a 0.13-mm opening did not produce hypertension. Four weeks after clipping, two-kidney, one clip hypertensive mice exhibited blood pressure approximately 20 mm Hg higher than their sham-operated controls. After a similar period, this increase reached almost 35 mm Hg in the one-kidney, one clip model. Depending on the model, mice develop either renin-dependent or renin-independent hypertension. Both models are characterized by the development of cardiovascular hypertrophy.
Keywords
Animals, Base Sequence, Blood Pressure, Blotting, Northern, Cardiomegaly, Heart Rate, Hemodynamics, Hypertension, Renovascular, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Polymerase Chain Reaction, RNA, Renin
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 16:00