Epinephrine sensitivity with respect to metabolic rate and other variables in women.

Details

Serval ID
serval:BIB_DB7BBC96A274
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epinephrine sensitivity with respect to metabolic rate and other variables in women.
Journal
AJP: Endocrinology and Metabolism
Author(s)
Sjöström L., Schutz Y., Gudinchet F., Hegnell L., Pittet P.G., Jéquier E.
ISSN
0193-1849
0002-9513
Publication state
Published
Issued date
11/1983
Volume
245
Number
5 Pt 1
Pages
E431-E442
Language
english
Notes
Publication types: Journal Article
Abstract
A test for determination of epinephrine sensitivity has been worked out using six healthy young women. Variables considered were metabolic rate, heart rate, respiratory frequency, blood pressure, blood glucose, plasma insulin, glycerol, free fatty acids, and lactate. After established basal conditions, epinephrine was infused at rates of 0.01, 0.03, and 0.1 microgram X kg fat-free mass-1 X min-1. Most variables responded to epinephrine in a dose-dependent manner. Physiological threshold plasma concentrations of epinephrine ranged from 95 to 250 pg/ml for different variables. Calculated maximal responses ranged from approximately -15% to +900% of basal values and infusion rates giving half-maximal responses from approximately 15 to 190 ng X kg fat-free mass-1 X min-1. On an average, metabolic rate increased by 8, 16, and 29%, respectively, at the three infusion rates, and the maximal metabolic response was calculated to be approximately 35%. The error in determining epinephrine-induced increments in metabolic rate was 7% of the response. As calculated from nonprotein RQ, carbohydrate oxidation increased and lipid oxidation decreased rapidly during the first 10 min of epinephrine infusion. Later, fat oxidation became more important. Results on epinephrine plasma metabolic clearance rate agreed with earlier results in the literature.
Keywords
Adult, Basal Metabolism/drug effects, Blood Glucose/metabolism, Blood Pressure/drug effects, Energy Metabolism/drug effects, Epinephrine/pharmacology, Fatty Acids, Nonesterified/blood, Female, Glycerol/blood, Heart Rate/drug effects, Humans, Insulin/blood, Kinetics, Lactates/blood, Lactic Acid, Respiration/drug effects
Pubmed
Web of science
Create date
08/04/2008 14:38
Last modification date
20/08/2019 16:00
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