Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels.

Details

Serval ID
serval:BIB_DA3C8B44EDA7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels.
Journal
Journal of Pharmacology and Experimental Therapeutics
Author(s)
Aubert J.F., Burnier M., Waeber B., Nussberger J., Dipette D.J., Burris J.F., Brunner H.R.
ISSN
0022-3565
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
244
Number
3
Pages
1109-1115
Language
english
Notes
Publication types: Journal Article
Abstract
Neuropeptide Y (NPY) is a peptide with vasoconstrictor properties known to be present in the central nervous system as well as in sympathetic nerve endings and the adrenal medulla. The purposes of this study were to investigate in normotensive conscious rats the effects of nonpressor doses of NPY on cardiac output and regional blood flow distribution (using radiolabeled microspheres) as well as on plasma renin activity, plasma catecholamine and vasopressin levels. NPY (0.1 microgram/min) infused i.v. for 30 min modified neither blood pressure nor heart rate. Cardiac index was at comparable levels in NPY- as in vehicle-treated rats (17.7 +/- 1.6, n = 8, vs. 21.3 +/- 0.9 ml/min/100 g, n = 8, mean +/- S.E.M.). There was no significant difference in regional blood flow distribution between the two groups of rats, except for the large intestine (0.42 +/- 0.06 vs. 0.71 +/- 0.1 ml/min/g in NPY- and vehicle-treated rats, respectively, P less than .05). Basal plasma renin activity and catecholamine levels were not modified by NPY whereas plasma vasopressin levels were lower (P less than .05) in rats given NPY (0.76 +/- 0.3 pg/ml, n = 8) than in those having received the vehicle (2.2 +/- 0.4 pg/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Animals, Arginine Vasopressin, Blood Pressure, Cardiac Output, Catecholamines, Male, Neuropeptide Y, Phentolamine, Rats, Rats, Inbred Strains, Regional Blood Flow, Renin
Pubmed
Web of science
Create date
25/01/2008 13:56
Last modification date
20/08/2019 16:59
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