Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses.

Details

Serval ID
serval:BIB_DA2E5C1D1F4D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses.
Journal
Journal of Infectious Diseases
Author(s)
Erard V., Chien J.W., Kim H.W., Nichols W.G., Flowers M.E., Martin P.J., Corey L., Boeckh M.
ISSN
0022-1899
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
193
Number
12
Pages
1619-1625
Language
english
Abstract
We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with respiratory-tract virus infection during the initial 100 days after HCT, 50 (38%) developed airflow decline < or =1 year after HCT. Lower-respiratory-tract infection with parainfluenza (odds ratio [OR], 17.9 [95% confidence interval {CI}, 2.0-160]; P=.01) and respiratory syncytial virus (OR, 3.6 [95% CI, 1.0-13]; P=.05) independently increased the risk of development of airflow decline < or =1 year after HCT. The airflow decline was immediately detectable after infection and was strongest for lower-respiratory-tract infection with parainfluenza virus; it stabilized during the months after the respiratory-tract virus infection, but, at < or =1 year after HCT, the initial lung function was not restored. Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization.
Keywords
Adult, Community-Acquired Infections/physiopathology, Community-Acquired Infections/virology, Cytomegalovirus Infections/physiopathology, Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Paramyxoviridae Infections/physiopathology, Pneumonia, Viral/physiopathology, Pulmonary Ventilation, Respiratory Syncytial Virus Infections/physiopathology, Respiratory Tract Infections/physiopathology, Respiratory Tract Infections/virology, Retrospective Studies, Risk Factors, Transplantation, Homologous
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2010 16:33
Last modification date
20/08/2019 15:59
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