Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens.

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Version: Final published version
Serval ID
serval:BIB_D9CFEA5BF1AA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens.
Journal
Cancer Research
Author(s)
Baumgaertner P., Rufer N., Devevre E., Derre L., Rimoldi D., Geldhof C., Voelter V., Liénard D., Romero P., Speiser D.E.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
66
Number
4
Pages
1912-1916
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. PDF type: Priority Report
Abstract
Clinical trials have shown that strong tumor antigen-specific CD8 T-cell responses are difficult to induce but can be achieved for T-cells specific for melanoma differentiation antigens, upon repetitive vaccination with stable emulsions prepared with synthetic peptides and incomplete Freund's adjuvant. Here, we show in four melanoma patients that ex vivo detectable T-cells and thus strong T-cell responses can also be induced against the more universal cancer-testis antigens NY-ESO-1 and Mage-A10. Interestingly, all patients had ex vivo detectable T-cell responses against multiple antigens after serial vaccinations with three peptides emulsified in incomplete Freund's adjuvant. Antigen-specific T-cells displayed an activated phenotype and secreted IFNgamma. The robust immune responses provide a solid basis for further development of human T-cell vaccination.
Keywords
Antigens, Neoplasm/immunology, CD8-Positive T-Lymphocytes/immunology, Cancer Vaccines/adverse effects, Cancer Vaccines/immunology, Cell Differentiation/immunology, Cross Reactions, Epitopes, T-Lymphocyte/immunology, HLA-A2 Antigen/immunology, Humans, Immunologic Memory, Lymphocyte Activation, MART-1 Antigen, Melanoma/immunology, Melanoma/therapy, Membrane Proteins/immunology, Neoplasm Proteins/immunology, Skin Neoplasms/immunology, Skin Neoplasms/therapy
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:28
Last modification date
20/08/2019 15:59
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