Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_D95F2287121D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain.
Journal
Current opinion in biotechnology
Author(s)
Jung J.Y., Ried M.K., Hothorn M., Poirier Y.
ISSN
1879-0429 (Electronic)
ISSN-L
0958-1669
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
49
Pages
156-162
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity. Genetic and biochemical studies revealed that PP-InsPs serve as ligands for the SPX domain. Residues in the PHO1 SPX domain involved in PP-InsPs binding are critical for its Pi export activity, and the interaction between SPX proteins and the PHR1 transcription factor, which results in PHR1 inactivation, is promoted by PP-InsPs. Changes in PP-InsPs levels in response to Pi deficiency may thus contribute to the adaptation of plants to stress via the modulation of the activity of SPX-containing proteins and their interactors. Modulating PP-InsP levels or the affinity/specificity of the SPX domain for PP-InsP could potentially be used to engineer crops to maintain high yield under reduced Pi fertilizer input.
Keywords
Biological Transport, Homeostasis, Inositol Phosphates/metabolism, Phosphates/metabolism, Plants/chemistry, Plants/metabolism, Transcription Factors/metabolism
Pubmed
Web of science
Create date
13/03/2018 16:38
Last modification date
20/08/2019 16:58
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