Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.
Details
Serval ID
serval:BIB_D910A818B30C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.
Journal
Clinical Cancer Research
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Publication state
Published
Issued date
2011
Volume
17
Number
7
Pages
1984-1997
Language
english
Notes
Publication types: Clinical Trial, Phase I ; Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Keywords
Adult, Aged, Aged, 80 and over, Antigens, CD3/metabolism, Antigens, CD8/metabolism, Antigens, Neoplasm/immunology, Apoptosis/drug effects, Cancer Vaccines/adverse effects, Cancer Vaccines/therapeutic use, Dendritic Cells/drug effects, Dendritic Cells/immunology, Drug Synergism, Erythema/etiology, Female, HLA-A Antigens/metabolism, Humans, Immunotherapy, Active, Interferon-gamma/secretion, Interleukin-15/immunology, Interleukin-15/pharmacology, Interleukin-2/immunology, Interleukin-2/pharmacology, Langerhans Cells/drug effects, Langerhans Cells/immunology, Lymphocyte Activation, Male, Melanoma/immunology, Melanoma/therapy, Middle Aged, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Cytotoxic/physiology, T-Lymphocytes, Regulatory/drug effects, T-Lymphocytes, Regulatory/physiology
Pubmed
Web of science
Create date
25/10/2011 13:17
Last modification date
20/08/2019 15:58
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