Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.

Détails

ID Serval
serval:BIB_D910A818B30C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.
Périodique
Clinical Cancer Research
Auteur(s)
Romano E., Rossi M., Ratzinger G., de Cos M.A., Chung D.J., Panageas K.S., Wolchok J.D., Wolchock J.D., Houghton A.N., Chapman P.B., Heller G., Yuan J., Young J.W.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Statut éditorial
Publié
Date de publication
2011
Volume
17
Numéro
7
Pages
1984-1997
Langue
anglais
Notes
Publication types: Clinical Trial, Phase I ; Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Mots-clé
Adult, Aged, Aged, 80 and over, Antigens, CD3/metabolism, Antigens, CD8/metabolism, Antigens, Neoplasm/immunology, Apoptosis/drug effects, Cancer Vaccines/adverse effects, Cancer Vaccines/therapeutic use, Dendritic Cells/drug effects, Dendritic Cells/immunology, Drug Synergism, Erythema/etiology, Female, HLA-A Antigens/metabolism, Humans, Immunotherapy, Active, Interferon-gamma/secretion, Interleukin-15/immunology, Interleukin-15/pharmacology, Interleukin-2/immunology, Interleukin-2/pharmacology, Langerhans Cells/drug effects, Langerhans Cells/immunology, Lymphocyte Activation, Male, Melanoma/immunology, Melanoma/therapy, Middle Aged, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Cytotoxic/physiology, T-Lymphocytes, Regulatory/drug effects, T-Lymphocytes, Regulatory/physiology
Pubmed
Web of science
Création de la notice
25/10/2011 14:17
Dernière modification de la notice
03/03/2018 21:52
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