Allergologie: 2. Mastocytose systémique--nouvelles stratégies thérapeutiques [Systemic mastocytosis--new therapeutic strategies].

Details

Serval ID
serval:BIB_D8E4A67BD0EC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Allergologie: 2. Mastocytose systémique--nouvelles stratégies thérapeutiques [Systemic mastocytosis--new therapeutic strategies].
Journal
Revue Médicale Suisse
Author(s)
Maniu C.M., Ribi C., Spertini F.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2013
Volume
9
Number
368
Pages
17-21
Language
french
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Abstract
Systemic mastocytosis is characterized by an excessive proliferation of mast cells and their accumulation in different organs. Avoidance of trigger factors leading to anaphylaxis is a general measure valid for all forms of mastocytosis. A premedication is necessary in case of surgery, anesthesia or administration of radiocontrast agents. Symptomatic treatment comprises antihistamines, anti-leukotrienes, proton pump inhibitors and topical corticosteroids. Indolent mastocytosis with refractory symptoms, the rare cases of aggressive mastocytosis with organ dysfunction and the even rarer mast cell leukemia require cytoreductive therapy. First-line agents are interferon alpha 2b and imatinib, a tyrosine kinase inhibitor. To date there is no curative treatment.
Keywords
Allergy and Immunology/trends, Anti-Inflammatory Agents/therapeutic use, Cladribine/therapeutic use, Humans, Interferon-alpha/therapeutic use, Mastocytosis, Systemic/diagnosis, Mastocytosis, Systemic/prevention & control, Medical Oncology/methods, Medical Oncology/trends, Protein Kinase Inhibitors/therapeutic use, Recombinant Proteins/therapeutic use, Therapies, Investigational/methods, Therapies, Investigational/trends
Pubmed
Create date
26/02/2013 14:51
Last modification date
20/08/2019 15:58
Usage data