Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_D761E6C388AC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.
Journal
Current Genetics
Author(s)
Tamás M.J., Fauvet B., Christen P., Goloubinoff P.
ISSN
1432-0983 (Electronic)
ISSN-L
0172-8083
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
64
Number
1
Pages
177-181
Language
english
Abstract
Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.

Keywords
Cadmium, Metal toxicity, Molecular chaperones, Protein aggregation, Protein folding, Saccharomyces cerevisiae
Pubmed
Web of science
Open Access
Yes
Create date
15/03/2018 9:04
Last modification date
20/08/2019 15:57
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