Role and organization of the actin cytoskeleton during cell-cell fusion.

Details

Serval ID
serval:BIB_D6463F068FE7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Role and organization of the actin cytoskeleton during cell-cell fusion.
Journal
Seminars in cell & developmental biology
Author(s)
Martin S.G.
ISSN
1096-3634 (Electronic)
ISSN-L
1084-9521
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
60
Pages
121-126
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes. This process requires fusogenic machineries to promote plasma membrane merging, and also relies on the organization of dedicated sub-cortical cytoskeletal assemblies. This review describes the role of actin structures, so called actin fusion foci, essential for the fusion of two distinct cell types: Drosophila myoblast cells, which fuse to form myotubes, and sexually differentiated cells of the fission yeast Schizosaccharomyces pombe, which fuse to form a zygote. I describe the respective composition and organization of the two structures, discuss their proposed role in promoting plasma membrane apposition, and consider the universality of similar structures for cell-cell fusion.

Keywords
Actin Cytoskeleton/metabolism, Actins/chemistry, Actins/metabolism, Animals, Cell Fusion, Humans, Myoblasts/cytology, Myoblasts/metabolism, Schizosaccharomyces/cytology, Actin fusion focus, Arp2/3, Cell fusion, Drosophila, Fertilization, Formin, Myoblast, Schizosaccharomyces pombe
Pubmed
Web of science
Create date
04/08/2016 18:55
Last modification date
03/03/2018 21:46
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