Connexins protect mouse pancreatic β cells against apoptosis.

Details

Serval ID
serval:BIB_D563A9D1CAC6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Connexins protect mouse pancreatic β cells against apoptosis.
Journal
Journal of Clinical Investigation
Author(s)
Klee P., Allagnat F., Pontes H., Cederroth M., Charollais A., Caille D., Britan A., Haefliger J.A., Meda P.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Publication state
Published
Issued date
2011
Volume
121
Number
12
Pages
4870-4879
Language
english
Abstract
Type 1 diabetes develops when most insulin-producing β cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of β cells to this attack remain largely obscure. Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic islets, protects mouse β cells against both cytotoxic drugs and cytokines that prevail in the islet environment at the onset of type 1 diabetes. We documented that this protection was at least partially dependent on intercellular communication, which Cx36 and other types of connexin channels establish within pancreatic islets. We further found that proinflammatory cytokines decreased expression of Cx36 and that experimental reduction or augmentation of Cx36 levels increased or decreased β cell apoptosis, respectively. Thus, we conclude that Cx36 is central to β cell protection from toxic insults.
Pubmed
Web of science
Open Access
Yes
Create date
05/01/2012 17:28
Last modification date
20/08/2019 16:55
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