A topological view of the replicon.

Details

Serval ID
serval:BIB_D45AFC5D567F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A topological view of the replicon.
Journal
EMBO Reports
Author(s)
Schvartzman J.B., Stasiak A.
ISSN
1469-221X[print], 1469-221X[linking]
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
5
Number
3
Pages
256-261
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases.
Keywords
DNA Replication, DNA Topoisomerase IV/metabolism, DNA Topoisomerases/metabolism, DNA, Circular/biosynthesis, DNA, Circular/chemistry, DNA, Superhelical/metabolism, Replicon
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 10:36
Last modification date
20/08/2019 15:54
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