A topological view of the replicon.

Détails

ID Serval
serval:BIB_D45AFC5D567F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A topological view of the replicon.
Périodique
EMBO Reports
Auteur(s)
Schvartzman J.B., Stasiak A.
ISSN
1469-221X[print], 1469-221X[linking]
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
5
Numéro
3
Pages
256-261
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases.
Mots-clé
DNA Replication, DNA Topoisomerase IV/metabolism, DNA Topoisomerases/metabolism, DNA, Circular/biosynthesis, DNA, Circular/chemistry, DNA, Superhelical/metabolism, Replicon
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 11:36
Dernière modification de la notice
20/08/2019 16:54
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