Newer Antiepileptic Drugs for Status Epilepticus in Adults: What's the Evidence?

Details

Serval ID
serval:BIB_D4180DD604D8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Newer Antiepileptic Drugs for Status Epilepticus in Adults: What's the Evidence?
Journal
CNS drugs
Author(s)
Beuchat I., Novy J., Rossetti A.O.
ISSN
1179-1934 (Electronic)
ISSN-L
1172-7047
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
32
Number
3
Pages
259-267
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Status epilepticus (SE) is one of the most frequent neurological emergencies. Despite this, understanding of its pathophysiology and evidence regarding its management is limited. Rapid, effective, and well-tolerated treatment to achieve seizure cessation is advocated to prevent brain damage or potentially lethal outcomes. The last two decades have witnessed an exponential increase in the number of available antiepileptic drugs (AEDs). These compounds, especially lacosamide and levetiracetam, in view of their intravenous formulation, have been increasingly prescribed in SE. These and other newer AEDs present a promising profile in terms of tolerability, with few centrally depressive effects, favorable pharmacokinetic properties, and fewer drug interactions than classical AEDs; conversely, they are more expensive. There is still no clear evidence to suggest a specific beneficial impact of newer AEDs on SE outcome, preventing any strong recommendation regarding their prescription in SE. Further comparative studies are urgently required to clarify their place and optimal use in the armamentarium of SE treatment.
Keywords
Administration, Intravenous, Adult, Anticonvulsants/administration & dosage, Anticonvulsants/pharmacokinetics, Diet Therapy, Drug Approval, Humans, Status Epilepticus/diet therapy, Status Epilepticus/drug therapy, Treatment Outcome
Pubmed
Web of science
Create date
29/03/2018 18:18
Last modification date
20/08/2019 16:54
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