Perivascular medical devices and drug delivery systems: Making the right choices.

Details

Serval ID
serval:BIB_D2B519231867
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Perivascular medical devices and drug delivery systems: Making the right choices.
Journal
Biomaterials
Author(s)
Mylonaki I., Allémann É., Saucy F., Haefliger J.A., Delie F., Jordan O.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Publication state
Published
Issued date
06/2017
Peer-reviewed
Oui
Volume
128
Pages
56-68
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Perivascular medical devices and perivascular drug delivery systems are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury. Despite abundant reports in the literature and numerous clinical trials, no efficient perivascular treatment is available. In this review, the existing perivascular medical devices and perivascular drug delivery systems, such as polymeric gels, meshes, sheaths, wraps, matrices, and metal meshes, are jointly evaluated. The key criteria for the design of an ideal perivascular system are identified. Perivascular treatments should have mechanical specifications that ensure system localization, prolonged retention and adequate vascular constriction. From the data gathered, it appears that a drug is necessary to increase the efficacy of these systems. As such, the release kinetics of pharmacological agents should match the development of the pathology. A successful perivascular system must combine these optimized pharmacological and mechanical properties to be efficient.

Keywords
Animals, Blood Vessels/physiology, Blood Vessels/physiopathology, Clinical Trials as Topic, Drug Delivery Systems, Drug Liberation, Equipment and Supplies, Humans, Tissue Distribution, Cuff, Intimal hyperplasia, Mesh, Periadventitial administration, Perivascular administration, Wrap
Pubmed
Web of science
Create date
21/03/2017 19:08
Last modification date
20/08/2019 16:52
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