A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Details

Serval ID
serval:BIB_D22C195AD634
Type
Article: article from journal or magazin.
Collection
Publications
Title
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
Journal
Neuron
Author(s)
Eliava M., Melchior M., Knobloch-Bollmann H.S., Wahis J., da Silva Gouveia M., Tang Y., Ciobanu A.C., Triana Del Rio R., Roth L.C., Althammer F., Chavant V., Goumon Y., Gruber T., Petit-Demoulière N., Busnelli M., Chini B., Tan L.L., Mitre M., Froemke R.C., Chao M.V., Giese G., Sprengel R., Kuner R., Poisbeau P., Seeburg P.H., Stoop R., Charlet A., Grinevich V.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
89
Number
6
Pages
1291-1304
Language
english
Abstract
Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2016 19:17
Last modification date
20/08/2019 16:52
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