Epidemiology of hypospadias in Europe: a registry-based study.

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Serval ID
serval:BIB_D2139E13E20F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epidemiology of hypospadias in Europe: a registry-based study.
Journal
World Journal of Urology
Author(s)
Bergman J.E., Loane M., Vrijheid M., Pierini A., Nijman R.J., Addor M.C., Barisic I., Béres J., Braz P., Budd J., Delaney V., Gatt M., Khoshnood B., Klungsøyr K., Martos C., Mullaney C., Nelen V., Neville A.J., O'Mahony M., Queisser-Luft A., Randrianaivo H., Rissmann A., Rounding C., Tucker D., Wellesley D., Zymak-Zakutnia N., Bakker M.K., de Walle H.E.
ISSN
1433-8726 (Electronic)
ISSN-L
0724-4983
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
33
Number
12
Pages
2159-2167
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Hypospadias is a common congenital malformation. The prevalence of hypospadias has a large geographical variation, and recent studies have reported both increasing and decreasing temporal trends. It is unclear whether hypospadias prevalence is associated with maternal age.
AIM: To analyze the prevalence and trends of total hypospadias, isolated hypospadias, hypospadias with multiple congenital anomalies, hypospadias with a known cause, and hypospadias severity subtypes in Europe over a 10-year period and to investigate whether maternal age is associated with hypospadias.
METHODS: We included all children with hypospadias born from 2001 to 2010 who were registered in 23 EUROCAT registries. Information on the total number of births and maternal age distribution for the registry population was also provided. We analyzed the total prevalence of hypospadias and relative risks by maternal age.
RESULTS: From 2001 to 2010, 10,929 hypospadias cases were registered in 5,871,855 births, yielding a total prevalence of 18.61 per 10,000 births. Prevalence varied considerably between different registries, probably due to differences in ascertainment of hypospadias cases. No significant temporal trends were observed with the exceptions of an increasing trend for anterior and posterior hypospadias and a decreasing trend for unspecified hypospadias. After adjusting for registry effects, maternal age was not significantly associated with hypospadias.
CONCLUSIONS: Total hypospadias prevalence was stable in 23 EUROCAT registries from 2001 to 2010 and was not significantly influenced by maternal age.
Keywords
Europe/epidemiology, Female, Humans, Hypospadias/complications, Hypospadias/epidemiology, Infant, Newborn, Male, Maternal Age, Prevalence, Registries, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2016 9:11
Last modification date
20/08/2019 15:52
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