REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson.

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State: Public
Version: Final published version
Serval ID
serval:BIB_D14A08C15443
Type
Article: article from journal or magazin.
Collection
Publications
Title
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson.
Journal
Movement Disorders
Author(s)
Benninger D.H., Michel J., Waldvogel D., Candia V., Poryazova R., van Hedel H.J., Bassetti C.L.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
2010
Volume
25
Number
11
Pages
1597-1604
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
To evaluate a potential association of REM-sleep behavior disorder (RBD) with gait and postural impairment in Parkinson's disease (PD). Gait difficulties and postural impairment are frequent in PD and are a major cause of disability. Animal studies indicate a key role of the pedunculopontine nucleus (PPN) in gait, postural control, and REM sleep, and also in the pathophysiology of RBD. In humans, such an association has not been investigated. Twenty-six patients with mild-to-moderate PD (13 with polysomnography confirmed and 13 with excluded RBD), and 20 age-matched healthy controls were prospectively investigated. Gait assessment on a treadmill, and static and dynamic posturography were performed. PD patients with RBD do not differ from those without RBD in gait and postural control. Greater severity of PD or prevalence of gait and postural disturbances in the presence of RBD were not found. RBD was not associated with any particular motor phenotype. We found no association of RBD with gait disturbances and postural impairment. Human gait and postural control and RBD appear to depend upon different neuronal circuits.
Keywords
Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gait Disorders, Neurologic/etiology, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease/complications, Polysomnography, Postural Balance/physiology, REM Sleep Behavior Disorder/etiology, Retrospective Studies, Severity of Illness Index, Statistics, Nonparametric
Pubmed
Web of science
Create date
08/10/2012 9:42
Last modification date
20/08/2019 15:51
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