REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_D14A08C15443
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson.
Périodique
Movement Disorders
Auteur(s)
Benninger D.H., Michel J., Waldvogel D., Candia V., Poryazova R., van Hedel H.J., Bassetti C.L.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
2010
Volume
25
Numéro
11
Pages
1597-1604
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
To evaluate a potential association of REM-sleep behavior disorder (RBD) with gait and postural impairment in Parkinson's disease (PD). Gait difficulties and postural impairment are frequent in PD and are a major cause of disability. Animal studies indicate a key role of the pedunculopontine nucleus (PPN) in gait, postural control, and REM sleep, and also in the pathophysiology of RBD. In humans, such an association has not been investigated. Twenty-six patients with mild-to-moderate PD (13 with polysomnography confirmed and 13 with excluded RBD), and 20 age-matched healthy controls were prospectively investigated. Gait assessment on a treadmill, and static and dynamic posturography were performed. PD patients with RBD do not differ from those without RBD in gait and postural control. Greater severity of PD or prevalence of gait and postural disturbances in the presence of RBD were not found. RBD was not associated with any particular motor phenotype. We found no association of RBD with gait disturbances and postural impairment. Human gait and postural control and RBD appear to depend upon different neuronal circuits.
Mots-clé
Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gait Disorders, Neurologic/etiology, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease/complications, Polysomnography, Postural Balance/physiology, REM Sleep Behavior Disorder/etiology, Retrospective Studies, Severity of Illness Index, Statistics, Nonparametric
Pubmed
Web of science
Création de la notice
08/10/2012 9:42
Dernière modification de la notice
20/08/2019 15:51
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