Epithelial sodium channel (ENaC) and the control of blood pressure.

Details

Serval ID
serval:BIB_D03B15751DA7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Epithelial sodium channel (ENaC) and the control of blood pressure.
Journal
Current Opinion In Pharmacology
Author(s)
Rossier B.C.
ISSN
1471-4973 (Electronic)
ISSN-L
1471-4892
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
15
Number
3
Pages
33-46
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of sodium balance, blood volume and blood pressure. In this review, we discuss recent advances in our understanding of ENaC function and regulation relevant to the control of sodium balance and blood pressure. The identification of novel drug targets should help in the development of the next generation of diuretics and of new therapies for the treatment of hypertension.
Keywords
Animals, Antihypertensive Agents/pharmacology, Blood Pressure/drug effects, Blood Pressure/physiology, Epithelial Sodium Channels/physiology, Humans, Molecular Targeted Therapy
Pubmed
Web of science
Create date
18/10/2016 13:33
Last modification date
20/10/2020 8:19
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