Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People

Details

Serval ID
serval:BIB_D02FB413F6AD
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Title
Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People
Title of the conference
82nd Scientific Session of the American Heart Association
Author(s)
Elliot Paul, Chambers John, Sehmi Joban, Clarke Robert, Erdmann Jeanette, Braund Peter, Engert James, Ashby Deborah, Tzoulaki Ionna, Peltonen Leena, Farrall Martin, Hamsten Anders, Froguel Phillipe, Waterworth Dawn, Vollenweider Peter, Waeber Gerrard, Jarvelin Marjo-Riitta, Scott James, Hall Alistair, Schunkert Heribert, Anand Sonia, Collins Rory, Samani Nilesh, Watkins Hugh, Kooner Jaspal
Address
Orlando, Florida, November 14-18, 2009
ISBN
0009-7322
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
120
Series
Circulation
Pages
467-468
Language
english
Notes
Meeting Abstract
Abstract
Background: C-reactive protein (CRP) is associated with risk of coronary heart disease (CHD). Whether CRP is causally associated with CHD or merely a marker of underlying atherosclerosis is uncertain.
Methods: We used a Mendelian randomisation design to investigate the causal relationship of CRP with CHD. We identified three genetic variants in the CRP locus (rs7553007, rs1130864 and rs1205) which influence CRP levels. We tested the three SNPs for association with CHD amongst 28,112 CHD cases and 100,823 controls. We then compared the observed relationship between the SNPs and CHD, with that predicted from the association of SNPs with CRP levels, and of CRP levels with CHD. Results: SNPs in the CRP locus were not associated with CHD: rs7553007, OR 0.98 (95% CI, 0.94-1.01); rs1130864, OR 1.00 (95% CI, 0.86-1.15); rs1205, OR 1.03 (95% CI, 0.99-1.07); combined OR for all three SNPs, 1.00 (95% CI, 0.97-1.02), per 20% lower CRP (figure). In contrast, the predicted OR for CHD from a 20% lower CRP level is 0.94 (95% CI, 0.94- 0.95), based on meta-analysis of observational studies.
Conclusions: Though CRP variants are associated with CRP levels, and CRP levels with risk of CHD, we observed that CRP variants are not associated with CHD risk. Our Mendelian randomisation experiment strongly argues against a causal association of CRP with CHD.
Web of science
Create date
24/02/2010 12:42
Last modification date
20/08/2019 16:50
Usage data